Scientist I, Toxicology

Scientist I, Toxicology

W2 Contract

Salary Range: $135,200 - $156,000 per year

Location: Redwood City, CA - Onsite Role

Job Summary:

We are seeking a highly motivated Scientist/Toxicologist to lead investigative safety strategies for small molecule and emerging modalities and work in close collaboration with colleagues across our Research and Development organizations to enable the advancement of portfolio programs. The successful candidate will bring a strong investigative understanding of the mechanisms of toxicity and deliver bespoke predictive models of toxicity and nonclinical safety assessment strategies.

Duties and Responsibilities:

• Function primarily as an investigative toxicologist to develop and deliver novel approach methods (NAMs), including predictive 2D and 3D models for nonclinical safety assessments.
• Design, execute, and deliver in vitro/ex vivo assays to detect and derisk toxicities for candidate drug molecules.
• Assess new technologies to support/improve compound toxicity prediction & screening, and development of translational/safety biomarkers.
• Design, analyze, and oversee in vivo studies to better understand mechanisms of toxicity and help develop mitigation strategies for our pipeline.
• Partner with internal and external collaborators and stakeholders related to integrated large-scale data analytics, computational, and chemical mining efforts.
• Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for patient safety.
• Design and oversee nonclinical toxicology programs to advance the pipeline of small-molecule cancer therapeutics by implementing target derisking, screening, in vivo testing strategies, risk mitigation, and investigation of toxicities.
• Effectively implement and oversee studies outsourced to CROs, in collaboration with study operations, pharmacology, DMPK, and clinical pharmacology functions.
• Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings with recommendations to internal project teams and leadership.
• Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and reviewing of nonclinical sections of regulatory documents.

Requirements and Qualifications:

• Ph.D. degree in Toxicology, Pharmacology, Immunology, Cancer biology, or related discipline with 0-1 year of relevant biotech/pharma drug discovery/development experience in a team-facing role.
• Strong scientific background and scientific aptitude, with excellent critical thinking and creative problem-solving skills.
• Ability to work effectively, independently, and collaboratively on cross-functional project teams; demonstrated ability to multitask, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.
• Experience with advanced cell culture approaches with immortalized cell lines, primary cells, whole blood, PBMCs, and iPSC cells.
• Cell and molecular biology techniques, including flow cytometry, Luminex/MSD, ELISA, and biomarker assay development and validation.
• Proven expertise in 3D cell culture systems such as tumor spheroids, organoids, complex in vitro models, and organ-on-a-chip models.
• Expertise in designing & delivering fit-for-purpose assays for understanding the mechanism of toxicity of agents, including small molecule drugs, for biomarker development and application, and for derisking drug candidates.
• Experience working in a matrixed team environment at a biotech/pharma company or CRO.
• Excellent verbal, oral, and written communication skills.
• Strong interpersonal and organizational skills.
• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high-energy, biotech company environment.

Preferred Qualifications:

• Experience working with small molecules and targeted oncology therapeutics of all modalities.
• Familiarity with GLPs and FDA/ICH guidance documents for nonclinical toxicology is desirable.

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.

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